PU-H54

Modify Date: 2024-01-10 19:10:34

PU-H54 Structure
PU-H54 structure
Common Name PU-H54
CAS Number 1454619-13-6 Molecular Weight 337.442
Density 1.2±0.1 g/cm3 Boiling Point 475.0±55.0 °C at 760 mmHg
Molecular Formula C18H19N5S Melting Point N/A
MSDS N/A Flash Point 241.1±31.5 °C

 Use of PU-H54


PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1].

 Names

Name 8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine
Synonym More Synonyms

 PU-H54 Biological Activity

Description PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1].
Related Catalog
References

[1]. Pallav D Patel, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9(11):677-84.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 475.0±55.0 °C at 760 mmHg
Molecular Formula C18H19N5S
Molecular Weight 337.442
Flash Point 241.1±31.5 °C
Exact Mass 337.136108
LogP 2.30
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.663

 Synonyms

8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine
3H-Purin-6-amine, 8-[(2,4-dimethylphenyl)thio]-3-(4-pentyn-1-yl)-
8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine
8-[(2,4-Dimethylphenyl)sulfanyl]-3-(4-pentyn-1-yl)-3H-purin-6-amine
PU-H54
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