PU 23

Modify Date: 2024-01-05 13:48:33

PU 23 structure	Common Name	PU 23
	CAS Number	817635-93-1	Molecular Weight	425.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉N₃O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PU 23

PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine[1].

Name	PU 23

Description	PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively[1]. Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells[1].
References	[1]. Ya Chen, et al. Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One. 2018 Oct 15;13(10):e0205175.

Molecular Formula	C₂₁H₁₉N₃O₃S₂
Molecular Weight	425.52
Storage condition	-20°C

DC Chemicals Limited
China
Product Name: PU 23
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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