168334-34-7
168334-34-7 structure
- Name: PU-141
- Chemical Name: PU-141
- CAS Number: 168334-34-7
- Molecular Formula: C14H9F3N2OS
- Molecular Weight: 310.294
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2020-01-11 16:48:49
- Modify Date: 2024-04-05 10:41:35
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PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM; blocks growth of SK-N-SH neuroblastoma xenografts in mice, also reduces histone lysine acetylation in vivo at concentrations that block neoplastic xenograft growth.
| Name | PU-141 |
|---|
| Description | PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM; blocks growth of SK-N-SH neuroblastoma xenografts in mice, also reduces histone lysine acetylation in vivo at concentrations that block neoplastic xenograft growth. |
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| References | References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT) |
| Molecular Formula | C14H9F3N2OS |
|---|---|
| Molecular Weight | 310.294 |
| Hazard Codes | Xi |
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