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PU-H54

Names

[ CAS No. ]:
1454619-13-6

[ Name ]:
PU-H54

[Synonym ]:
8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine
3H-Purin-6-amine, 8-[(2,4-dimethylphenyl)thio]-3-(4-pentyn-1-yl)-
8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine
8-[(2,4-Dimethylphenyl)sulfanyl]-3-(4-pentyn-1-yl)-3H-purin-6-amine
PU-H54

Biological Activity

[Description]:

PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Pallav D Patel, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9(11):677-84.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
475.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H19N5S

[ Molecular Weight ]:
337.442

[ Flash Point ]:
241.1±31.5 °C

[ Exact Mass ]:
337.136108

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.663

Related Compounds