Iodoacetamide

Modify Date: 2024-01-02 15:46:47

Iodoacetamide structure	Common Name	Iodoacetamide
	CAS Number	144-48-9	Molecular Weight	184.964
	Density	2.3±0.1 g/cm3	Boiling Point	297.1±23.0 °C at 760 mmHg
	Molecular Formula	C₂H₄INO	Melting Point	92-95 °C(lit.)
	MSDS	Chinese USA	Flash Point	133.5±22.6 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Iodoacetamide

2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2].

Name	2-Iodoacetamide
Synonym	More Synonyms

Description	2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	2-Iodoacetamide (2.0-10 mg; drinking; daily; 20-93 days) feeding always produces chronic deep ulcers in the secretory part of the rat stomach[2]. Animal Model: Sprague-Dawley rats[2] Dosage: 2.0-10 mg Administration: Drinking water, daily, for periods of 20 to 93 days Result: Produced gastritis which was further complicated by chronic ulceration in many of the test rats.
References	[1]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447. [2]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr;109:905-8.

Density	2.3±0.1 g/cm3
Boiling Point	297.1±23.0 °C at 760 mmHg
Melting Point	92-95 °C(lit.)
Molecular Formula	C₂H₄INO
Molecular Weight	184.964
Flash Point	133.5±22.6 °C
Exact Mass	184.933746
PSA	43.09000
LogP	-0.19
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.602
Storage condition	2-8°C
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids.
Water Solubility	slightly soluble

Iodoacetamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC4200000

CHEMICAL NAME :: Acetamide, 2-iodo-

CAS REGISTRY NUMBER :: 144-48-9

BEILSTEIN REFERENCE NO. :: 1739080

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H4-I-N-O

MOLECULAR WEIGHT :: 184.97

WISWESSER LINE NOTATION :: ZV1I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 umol/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 50,97,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4435 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H317-H334-H413
Precautionary Statements	P261-P280-P301 + P310-P342 + P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38;R43
Safety Phrases	S22-S36/37-S45-S37/39-S26-S24
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	AC4200000
Packaging Group	III
Hazard Class	6.1
HS Code	2924199090

iodoacetic anhydride

CAS#:54907-61-8

~66%

Iodoacetamide

CAS#:144-48-9

Literature: Molecular Probes, Inc. Patent: US5274113 A1, 1993 ;

2-Chloroacetamide

CAS#:79-07-2

Iodoacetamide

CAS#:144-48-9

Literature: Zeitschrift fuer Physikalische Chemie, Abteilung A: Chemische Thermodynamik, Kinetik, Elektrochemie, Eigenschaftslehre, , vol. 157, p. 249,254 Zeitschrift fuer Physikalische Chemie, Abteilung A: Chemische Thermodynamik, Kinetik, Elektrochemie, Eigenschaftslehre, , vol. 163, p. 38

Iodoacetonitrile

CAS#:624-75-9

Iodoacetamide

CAS#:144-48-9

Literature: Synthesis, , p. 574 - 575

Ethanol

CAS#:64-17-5

2-Chloroacetamide

CAS#:79-07-2

Iodoacetamide

CAS#:144-48-9

Literature: Chemische Berichte, , vol. 41, p. 2117 Chemische Berichte, , vol. 42, p. 2056

Precursor 4
CAS#:54907-61-8 iodoacetic anhydride CAS#:79-07-2 2-Chloroacetamide CAS#:624-75-9 Iodoacetonitrile CAS#:64-17-5 Ethanol
DownStream 10
CAS#:122275-78-9 3,3-dimethyl-5'... CAS#:14134-81-7 1-Ethyl-2,3,3-t... CAS#:123-93-3 thiodiacetic acid CAS#:505-73-7 Dithiodiglycoli...
CAS#:10034-85-2 Hydrogen iodide CAS#:64-19-7 acetic acid CAS#:7553-56-2 molecular iodine CAS#:60-35-5 Acetamide
CAS#:24466-68-0 (2-amino-2-oxoe... CAS#:25077-26-3 2,6-Piperidined...

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Vet. Parasitol. 207(3-4) , 266-75, (2015)

The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in lives...

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

Proteomic analysis of nasal epithelial cells from cystic fibrosis patients.

PLoS ONE 9(9) , e108671, (2014)

The pathophysiology of cystic fibrosis (CF) lung disease remains incompletely understood. New explanations for the pathogenesis of CF lung disease may be discovered by studying the patterns of protein...

MFCD00008028

carbamoylmethyl iodide

2-Iodo-acetamide

USAF D-1

Monoiodoacetamide

2-iodoacetamido

Acetamide, 2-iodo-

Iodoacetamide

ACETAMIDE,2-IODO

2-Iodoacetamide

Surauto

EINECS 205-630-1

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Iodoacetamide
Price: ￥418.0/25g ￥108.0/5g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 2-Iodoacetamide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Iodoacetamide
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Iodoacetamide
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-Iodoacetamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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Iodoacetamide

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