(S)-(+)-O-Desmethyl Venlafaxine

Modify Date: 2025-08-25 17:45:28

(S)-(+)-O-Desmethyl Venlafaxine structure	Common Name	(S)-(+)-O-Desmethyl Venlafaxine
	CAS Number	142761-12-4	Molecular Weight	263.37500
	Density	1.115g/cm3	Boiling Point	403.792ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₅NO₂	Melting Point	208-213ºC
	MSDS	N/A	Flash Point	193.192ºC

Use of (S)-(+)-O-Desmethyl Venlafaxine

(S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

Name	S-(+)-O-Desmethyl Venlafaxine
Synonym	More Synonyms

Description	(S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28. [2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

Description

Related Catalog

Research Areas >> Neurological Disease

References

[1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28.

[2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

Density	1.115g/cm3
Boiling Point	403.792ºC at 760 mmHg
Melting Point	208-213ºC
Molecular Formula	C₁₆H₂₅NO₂
Molecular Weight	263.37500
Flash Point	193.192ºC
Exact Mass	263.18900
PSA	43.70000
LogP	2.73260
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.573

R-VENLAFAXINE

CAS#:93413-46-8

~73%

(S)-(+)-O-Desme...

CAS#:142761-12-4

Literature: Solvay Pharmaceuticals, B.V. Patent: US2009/5455 A1, 2009 ; Location in patent: Page/Page column 7 ;

Precursor 1
CAS#:93413-46-8 R-VENLAFAXINE
DownStream 0

4-[(1S)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

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