(S)-(+)-O-Desmethyl Venlafaxine

Names

[ Name ]:
(S)-(+)-O-Desmethyl Venlafaxine

[Synonym ]:
4-[(1S)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

Biological Activity

[Description]:

(S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28.

[2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

Chemical & Physical Properties

[ Density]:
1.115g/cm3

[ Boiling Point ]:
403.792ºC at 760 mmHg

[ Melting Point ]:
208-213ºC

[ Molecular Formula ]:
C₁₆H₂₅NO₂

[ Molecular Weight ]:
263.37500

[ Flash Point ]:
193.192ºC

[ Exact Mass ]:
263.18900

[ PSA ]:
43.70000

[ LogP ]:
2.73260

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.573

(S)-(+)-O-Desmethyl Venlafaxine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds