PIM1-IN-1
Modify Date: 2024-01-10 09:11:34
PIM1-IN-1 structure
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Common Name | PIM1-IN-1 | ||
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| CAS Number | 1417630-95-5 | Molecular Weight | 474.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H30N8O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PIM1-IN-1PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1]. |
| Name | PIM1-IN-1 |
|---|
| Description | PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
PIM1:7 nM (IC50) PIM3:70 nM (IC50) PIM2:5530 nM (IC50) |
| In Vitro | PIM1-IN-1 (Compound 42) exhibits antiproliferative activity, with GI50 of 1.48 µM for melanoma cell line SKMEL-19. PIM1-IN-1 has significant synergistic effect combined with different antitumoral agents in different tumor cell lines[1]. PIM1-IN-1 (2.5, 5, or 10 µM, 24 hours) induces apoptosis in SKMEL19 cells[1]. Apoptosis Analysis[1] Cell Line: SKMEL19 cells Concentration: 2.5, 5, or 10 µM Incubation Time: 24 hours Result: Regulated cell cycle, induced cell apopsis in SKMEL19 cells. |
| In Vivo | PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice[1]. |
| References |
| Molecular Formula | C25H30N8O2 |
|---|---|
| Molecular Weight | 474.56 |