Tannic acid

Modify Date: 2024-01-02 08:18:21

Tannic acid Structure
Tannic acid structure
 Common Name Tannic acid
CAS Number 1401-55-4 Molecular Weight 1701.198
Density 2.1±0.1 g/cm3 Boiling Point N/A
Molecular Formula C76H52O46 Melting Point 218 °C(lit.)
MSDS Chinese USA Flash Point 198°C

 Use of Tannic acid


Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

 Names

Name tannic acid
Synonym More Synonyms

 Tannic acid Biological Activity

Description Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
Related Catalog
Target

IC50: 3.4 μM (hERG channel)[1]
In Vivo During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2].
Animal Admin Specific pathogen-free female 6 weeks old mice are used. The animals are maintained in a controlled room (temperature 23±2 °C, humidity 55±15%, 12 h light cycle). After 1 week, the mice arer andomly divided into 3 groups, untreated group-receive vehicle (distill water) (Normal, n=5); DfE cream treated mice (100 mg/mouse) is divided into two groups and each receives vehicle (distill water) (AD, n=5) or Tannic acid (80 mg/kg/day, per oral) (AD+Tannic acid, n=5) and are allowed free access to drinking water and standard laboratory diet[2].
References

[1]. Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12): e0143797.

[2]. Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76(2):206-13.

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Melting Point 218 °C(lit.)
Molecular Formula C76H52O46
Molecular Weight 1701.198
Flash Point 198°C
Exact Mass 1700.172974
PSA 777.98000
LogP 13.33
Index of Refraction 1.927
Stability Stable. Incompatible with metallic salts, strong oxidizing agents, iron and other heavy metals.
Water Solubility 250 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WU7185000
CHEMICAL NAME :
Sweet gum
CAS REGISTRY NUMBER :
1401-55-4
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg/56W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 57,207,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1577 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 62 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82010 No. of Facilities: 2362 (estimated) No. of Industries: 41 No. of Occupations: 51 No. of Employees: 22302 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1577 No. of Facilities: 1650 (estimated) No. of Industries: 19 No. of Occupations: 29 No. of Employees: 41974 (estimated) No. of Female Employees: 19715 (estimated)

 Safety Information

Hazard Statements H412
Precautionary Statements P273
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R40
Safety Phrases 24/25-36-26-36/37/39-22
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS WW5075000
HS Code 3201909000

 Customs

HS Code 3201909000

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 Synonyms

Tannic acid
Gallotannin,Tannin
MFCD00066397
EINECS 215-753-2
Gallotannin Tannin
Glycerite
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