Tannic acid

[Description]:

Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Natural Products >> Phenols

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

IC50: 3.4 μM (hERG channel)[1]

[In Vivo]

During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2].

[Animal admin]

Specific pathogen-free female 6 weeks old mice are used. The animals are maintained in a controlled room (temperature 23±2 °C, humidity 55±15%, 12 h light cycle). After 1 week, the mice arer andomly divided into 3 groups, untreated group-receive vehicle (distill water) (Normal, n=5); DfE cream treated mice (100 mg/mouse) is divided into two groups and each receives vehicle (distill water) (AD, n=5) or Tannic acid (80 mg/kg/day, per oral) (AD+Tannic acid, n=5) and are allowed free access to drinking water and standard laboratory diet[2].

[References]

[1]. Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12): e0143797.

[2]. Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76(2):206-13.

[Related Small Molecules]

[ Density]:
2.1±0.1 g/cm3

[ Melting Point ]:
218 °C(lit.)

[ Molecular Formula ]:
C₇₆H₅₂O₄₆

[ Molecular Weight ]:
1701.198

[ Flash Point ]:
198°C

[ Exact Mass ]:
1700.172974

[ PSA ]:
777.98000

[ LogP ]:
13.33

[ Index of Refraction ]:
1.927

[ Stability ]:
Stable. Incompatible with metallic salts, strong oxidizing agents, iron and other heavy metals.

[ Water Solubility ]:
250 g/L (20 ºC)

Click to get detail MSDS

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WU7185000

CHEMICAL NAME :: Sweet gum

CAS REGISTRY NUMBER :: 1401-55-4

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 57,207,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1577 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 62 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82010 No. of Facilities: 2362 (estimated) No. of Industries: 41 No. of Occupations: 51 No. of Employees: 22302 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1577 No. of Facilities: 1650 (estimated) No. of Industries: 19 No. of Occupations: 29 No. of Employees: 41974 (estimated) No. of Female Employees: 19715 (estimated)

[ Hazard Statements ]:
H412

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
24/25-36-26-36/37/39-22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
WW5075000

[ HS Code ]:
3201909000

[ HS Code ]: 3201909000

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