Bis-propargyl-PEG9

Modify Date: 2024-01-02 19:47:50

Bis-propargyl-PEG9 Structure
Bis-propargyl-PEG9 structure
Common Name Bis-propargyl-PEG9
CAS Number 1351373-47-1 Molecular Weight 490.584
Density 1.1±0.1 g/cm3 Boiling Point 529.5±45.0 °C at 760 mmHg
Molecular Formula C24H42O10 Melting Point N/A
MSDS N/A Flash Point 197.4±28.6 °C

 Use of Bis-propargyl-PEG9


Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].

 Names

Name Bis-Propargyl-PEG10
Synonym More Synonyms

 Bis-propargyl-PEG9 Biological Activity

Description Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 529.5±45.0 °C at 760 mmHg
Molecular Formula C24H42O10
Molecular Weight 490.584
Flash Point 197.4±28.6 °C
Exact Mass 490.277802
LogP -2.20
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.466
Storage condition 2-8°C

 Synonyms

MFCD28976686
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne
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