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1351373-47-1

1351373-47-1 structure
1351373-47-1 structure
  • Name: Bis-propargyl-PEG9
  • Chemical Name: Bis-Propargyl-PEG10
  • CAS Number: 1351373-47-1
  • Molecular Formula: C24H42O10
  • Molecular Weight: 490.584
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-11-14 18:26:40
  • Modify Date: 2024-01-02 19:47:50
  • Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].

Name Bis-Propargyl-PEG10
Synonyms MFCD28976686
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne
Description Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98.

Density 1.1±0.1 g/cm3
Boiling Point 529.5±45.0 °C at 760 mmHg
Molecular Formula C24H42O10
Molecular Weight 490.584
Flash Point 197.4±28.6 °C
Exact Mass 490.277802
LogP -2.20
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.466
Storage condition 2-8°C