Bis-propargyl-PEG9

Names

[ Name ]:
Bis-propargyl-PEG9

[Synonym ]:
MFCD28976686
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne

Biological Activity

[Description]:

Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
529.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₄₂O₁₀

[ Molecular Weight ]:
490.584

[ Flash Point ]:
197.4±28.6 °C

[ Exact Mass ]:
490.277802

[ LogP ]:
-2.20

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.466

[ Storage condition ]:
2-8°C

Related Compounds

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