Bis-propargyl-PEG2

Names

[ Name ]:
Bis-propargyl-PEG2

[Synonym ]:
3-[2-(2-prop-2-ynyloxyethoxy)ethoxy]propyne
bis-O-propargyl-di(ethylene glycol)
4,7,10-trioxahexadeca-1,12-diyne
4,7,10-trioxatrideca-1,12-diyne
bis(2-propynoxyethyl)ether
4,7,10-trioxatrideca-1,12-diine

Biological Activity

[Description]:

Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

Bis-propargyl-PEG2 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].

[References]

[1]. Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30.

[2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

Chemical & Physical Properties

[ Density]:
1.02g/mL

[ Boiling Point ]:
103 °C/0.8kPa

[ Molecular Formula ]:
C₁₀H₁₄O₃

[ Molecular Weight ]:
182.21600

[ Exact Mass ]:
182.09400

[ PSA ]:
27.69000

[ LogP ]:
0.30260

Related Compounds

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