BRK inhibitor P21d
Modify Date: 2025-09-12 17:17:40
BRK inhibitor P21d structure
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Common Name | BRK inhibitor P21d | ||
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| CAS Number | 1338249-87-8 | Molecular Weight | 447.474 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H22FN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRK inhibitor P21dBRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation. |
| Name | BRK inhibitor P21d |
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| Description | BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation. |
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| References | References 1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5. 2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17. View Related Products by Target Breast Tumor Kinase (BRK;PTK6) |
| Molecular Formula | C23H22FN7O2 |
|---|---|
| Molecular Weight | 447.474 |
| InChIKey | YLOQNKKMSVHVDC-UHFFFAOYSA-N |
| SMILES | O=C(c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)c(F)c1)N1CCOCC1 |