BRK inhibitor P21d

BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation.

References 1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5. 2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17. View Related Products by Target Breast Tumor Kinase (BRK;PTK6)