1338249-87-8
1338249-87-8 structure
- Name: BRK inhibitor P21d
- Chemical Name: BRK inhibitor P21d
- CAS Number: 1338249-87-8
- Molecular Formula: C23H22FN7O2
- Molecular Weight: 447.474
- Create Date: 2020-01-20 13:38:56
- Modify Date: 2024-09-19 09:21:02
-
BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation.
| Name | BRK inhibitor P21d |
|---|
| Description | BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation. |
|---|---|
| References | References 1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5. 2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17. View Related Products by Target Breast Tumor Kinase (BRK;PTK6) |
| Molecular Formula | C23H22FN7O2 |
|---|---|
| Molecular Weight | 447.474 |