BRK inhibitor P21d hydrochloride
Modify Date: 2025-08-26 19:03:55
BRK inhibitor P21d hydrochloride structure
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Common Name | BRK inhibitor P21d hydrochloride | ||
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| CAS Number | 2250025-98-8 | Molecular Weight | 483.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23ClFN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRK inhibitor P21d hydrochlorideBRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models[1]. |
| Name | BRK inhibitor P21d hydrochloride |
|---|
| Description | BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models[1]. |
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| Related Catalog | |
| Target |
IC50: 30 nM (BRK), 52 nM (p-SAM68), >20 μM (Aurora B), >20 μM (Lck)[1] |
| In Vitro | BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC50>20 μM) and Lck (IC50>20 μM)[1]. |
| In Vivo | BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC0–6h=31.1 μM•h,C6h=3.5 μM)[1]. |
| References |
| Molecular Formula | C23H23ClFN7O2 |
|---|---|
| Molecular Weight | 483.93 |
| InChIKey | GWHGHKMCIUENCZ-UHFFFAOYSA-N |
| SMILES | Cl.O=C(c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)c(F)c1)N1CCOCC1 |