ERK Inhibitor
Modify Date: 2024-01-03 02:35:42
ERK Inhibitor structure
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Common Name | ERK Inhibitor | ||
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| CAS Number | 1049738-54-6 | Molecular Weight | 328.814 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H17ClN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ERK InhibitorERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1]. |
| Name | 3-[(2-aminoethyl)-5-(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione hydrochloride |
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| Synonym | More Synonyms |
| Description | ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1]. |
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| Related Catalog | |
| Target |
ERK2:5 μM (Kd) |
| In Vitro | ERK-IN-4（化合物 76；10-75 µM；10 天）完全抑制细胞增殖，并减少细胞集落数量[1]。 ERK-IN-4（化合物 76；100 µM）抑制 ERK 介导的 Thr573 上 Rsk-1 磷酸化和 ERK 介导的 HeLa 细胞中的 Elk-1 磷酸化[1]。 Cell Proliferation Assay[1] Cell Line: HeLa, A549, or SUM-159 cells Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 150 µM for A549, or SUM-159 cells; 25 µM, 50 µM, 75 µM for HeLa cells Incubation Time: 10 days Result: Completely inhibited cell proliferation. |
| References |
| Molecular Formula | C14H17ClN2O3S |
|---|---|
| Molecular Weight | 328.814 |
| Exact Mass | 328.064850 |
| PSA | 97.93000 |
| LogP | 3.52050 |
| Storage condition | -20°C |
| (5Z)-3-(2-Aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione hydrochloride (1:1) |
| erk inhibitor |
| 2,4-Thiazolidinedione, 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-, (5Z)-, hydrochloride (1:1) |