1177970-73-8

1177970-73-8 structure

Name: ERK Inhibitor II (Negative control)
Chemical Name: 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydropyrazolo[3,4-c]pyridazin-3-one
CAS Number: 1177970-73-8
Molecular Formula: C₁₈H₁₂N₆O
Molecular Weight: 328.32700
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2017-07-10 10:23:15
Modify Date: 2024-01-11 20:28:20
ERK Inhibitor II (Negative control) is an effective inhibitor of extracellular signal-regulated kinase (ERK). ERK Inhibitor II (Negative control) inhibits the activation of insulin receptor, which can be used in the study of diabetes[1][2].

Name	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydropyrazolo[3,4-c]pyridazin-3-one
Synonyms	HMS3229G08 ERK Inhibitor II,Negative Control

Description	ERK Inhibitor II (Negative control) is an effective inhibitor of extracellular signal-regulated kinase (ERK). ERK Inhibitor II (Negative control) inhibits the activation of insulin receptor, which can be used in the study of diabetes[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	ERK Inhibitor II (Negative control) ( Irfin1) (10 µM) 抑制 CHO-K1 细胞中胰岛素诱导的胰岛素受体 (IR) 激活[2]。
References	[1]. Rezania A, et al. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage. World Intellectual Property Organization. WO2010051223. [2]. Anastassiadis T, et al. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J Biol Chem. 2013 Sep 27;288(39):28068-77.