GSK 2194069

Modify Date: 2024-01-02 01:22:16

GSK 2194069 Structure
GSK 2194069 structure
Common Name GSK 2194069
CAS Number 1332331-08-4 Molecular Weight 428.48300
Density N/A Boiling Point N/A
Molecular Formula C25H24N4O3 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of GSK 2194069


GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM in an assay detecting released CoA.IC50 value: Target: hFAS inhibitor

 Names

Name 4-[4-(1-benzofuran-5-yl)phenyl]-5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Synonym More Synonyms

 GSK 2194069 Biological Activity

Description GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM in an assay detecting released CoA.IC50 value: Target: hFAS inhibitor
Related Catalog
References

[1]. Hardwicke MA, et al. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.

 Chemical & Physical Properties

Molecular Formula C25H24N4O3
Molecular Weight 428.48300
Exact Mass 428.18500
PSA 84.13000
LogP 3.71270
Storage condition 2-8℃

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310 + P330
RIDADR UN 2811 6.1 / PGIII

 Synonyms

gsk2194069
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