GSK 525768A
Modify Date: 2024-01-12 15:37:35
GSK 525768A structure
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Common Name | GSK 525768A | ||
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| CAS Number | 1260530-25-3 | Molecular Weight | 423.89500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK 525768AGSK 525768A is the inactive enantiomer of GSK525762A. GSK 525768A has no activity towards BET. |
| Name | 2-[(4R)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide |
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| Synonym | More Synonyms |
| Description | GSK 525768A is the inactive enantiomer of GSK525762A. GSK 525768A has no activity towards BET. |
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| Related Catalog | |
| In Vitro | GSK 525768A has no activity towards BET[1]. GSK 525768A (GSK525768A) is the (R)-enantiomer of GSK525762A. GSK525762A is shown to regulate levels of the high-density lipid protein apolipoprotein A1 (APOA1) in assays monitoring APOA1 release in liver cells, whereas the (R)-enantiomer (GSK 525768A) has no effect. GSK 525768A directly engages the protein module by forming hydrogen bonds with the conserved asparagine residue in a way that mimics the binding mode of acetylated lysine; this usually results in the binding of the inhibitor deeper within the acetylated lysine binding site but without displacing the conserved water molecules that are present at the bottom of the acetyl-lysine binding cavity[2]. |
| References |
| Molecular Formula | C22H22ClN5O2 |
|---|---|
| Molecular Weight | 423.89500 |
| Exact Mass | 423.14600 |
| PSA | 84.89000 |
| LogP | 3.93190 |
| Storage condition | 2-8℃ |
| 2-[(4R)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide |
| CS-1255 |
| GSK 525768A |