1601496-05-2
1601496-05-2 structure
- Name: GSK-843
- Chemical Name: 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
- CAS Number: 1601496-05-2
- Molecular Formula: C19H15N5S2
- Molecular Weight: 377.49
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2018-06-23 00:29:48
- Modify Date: 2024-01-22 22:56:48
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GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].
| Name | 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine |
|---|---|
| Synonyms |
3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
Thieno[3,2-c]pyridin-4-amine, 3-(5-benzothiazolyl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)- |
| Description | GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.5 nM (RIP3)[1] |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 640.0±55.0 °C at 760 mmHg |
| Molecular Formula | C19H15N5S2 |
| Molecular Weight | 377.49 |
| Flash Point | 340.8±31.5 °C |
| Exact Mass | 377.076874 |
| LogP | 4.90 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.832 |
| Hazard Codes | Xi |
|---|