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GSK 2194069

Names

[ CAS No. ]:
1332331-08-4

[ Name ]:
GSK 2194069

[Synonym ]:
gsk2194069

Biological Activity

[Description]:

GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM in an assay detecting released CoA.IC50 value: Target: hFAS inhibitor

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Hardwicke MA, et al. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24N4O3

[ Molecular Weight ]:
428.48300

[ Exact Mass ]:
428.18500

[ PSA ]:
84.13000

[ LogP ]:
3.71270

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds