MMV-390048
Modify Date: 2024-01-14 20:08:33
MMV-390048 structure
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Common Name | MMV-390048 | ||
|---|---|---|---|---|
| CAS Number | 1314883-11-8 | Molecular Weight | 393.383 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 534.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H14F3N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 277.0±30.1 °C | |
Use of MMV-390048MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1]. |
| Name | 0Z5T00JJ10 |
|---|---|
| Synonym | More Synonyms |
| Description | MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1]. |
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| Related Catalog | |
| Target |
Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1] |
| In Vitro | MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.4±50.0 °C at 760 mmHg |
| Molecular Formula | C18H14F3N3O2S |
| Molecular Weight | 393.383 |
| Flash Point | 277.0±30.1 °C |
| Exact Mass | 393.075867 |
| LogP | 3.06 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.575 |
| 0Z5T00JJ10 |
| 5-[4-(Methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine |
| MFCD28502126 |
| [3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)- |