MMV-390048

Names

[ Name ]:
MMV-390048

[Synonym ]:
0Z5T00JJ10
5-[4-(Methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
MFCD28502126
[3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-

Biological Activity

[Description]:

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

Signaling Pathways >> PI3K/Akt/mTOR >> PI4K

[Target]

Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1]

[In Vitro]

MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.

[References]

[1]. Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
534.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₄F₃N₃O₂S

[ Molecular Weight ]:
393.383

[ Flash Point ]:
277.0±30.1 °C

[ Exact Mass ]:
393.075867

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.575

Related Compounds

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