1314883-11-8

1314883-11-8 structure

Name: MMV-390048
Chemical Name: 0Z5T00JJ10
CAS Number: 1314883-11-8
Molecular Formula: C₁₈H₁₄F₃N₃O₂S
Molecular Weight: 393.383
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-06-14 18:23:29
Modify Date: 2024-01-14 20:08:33
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

Name	0Z5T00JJ10
Synonyms	0Z5T00JJ10 5-[4-(Methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine MFCD28502126 [3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-

Description	MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> PI4K
Target	Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1]
In Vitro	MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.
References	[1]. Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.