N(4), O(2')-dimethylcytidine

Modify Date: 2025-09-15 17:18:49

N(4), O(2')-dimethylcytidine Structure
N(4), O(2')-dimethylcytidine structure
 Common Name N(4), O(2')-dimethylcytidine
CAS Number 13048-95-8 Molecular Weight 271.27
Density 1.54g/cm3 Boiling Point 475.4ºC at 760mmHg
Molecular Formula C11H17N3O5 Melting Point 203-205 °C
MSDS N/A Flash Point 241.3ºC

 Use of N(4), O(2')-dimethylcytidine


N4-Methyl-2’-O-methyl-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one
Synonym More Synonyms

 N(4), O(2')-dimethylcytidine Biological Activity

Description N4-Methyl-2’-O-methyl-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.54g/cm3
Boiling Point 475.4ºC at 760mmHg
Melting Point 203-205 °C
Molecular Formula C11H17N3O5
Molecular Weight 271.27
Flash Point 241.3ºC
Exact Mass 271.11700
PSA 109.33000
Vapour Pressure 4.91E-11mmHg at 25°C
Index of Refraction 1.636

 Safety Information

Hazard Codes Xn

 Synthetic Route

3',5'-di-O-acetyl-N4,2'-O-dimethylcytidine structure

3',5'-di-O-acet...

CAS#:1085342-83-1

~98%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Mahto, Santosh K.; Chow, Christine S. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8795 - 8800
4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine structure

4-N-methyl-3',5...

CAS#:110588-51-7

~92%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone structure

1-(3',5'-O-1,1,...

CAS#:108782-90-7

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone structure

1-(3',5'-O-1,1,...

CAS#:110567-19-6

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-((6aR,8R,9R,9aR)-2,2,4,4-tetraisopropyl-9-((trimethylsilyl)oxy)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione structure

1-((6aR,8R,9R,9...

CAS#:415903-48-9

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
Uridine structure

Uridine

CAS#:58-96-8

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
3',5'-O-(1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANEDIYL)URIDINE structure

3',5'-O-(1,1,3,...

CAS#:69304-38-7

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830

 Synonyms

N,2'-O-Dimethylcytidine
Cytidine,N-methyl-2'-O-methyl
N4,O2'-Dimethylcytidin
N4,2'-O-dimethylcytidine
N4-Methyl-2'-O-methyl-cytidin
N4,O2'-dimethyl-cytidine
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