N(4), O(2')-dimethylcytidine

Modify Date: 2026-08-06 16:09:33

N(4), O(2')-dimethylcytidine Structure
N(4), O(2')-dimethylcytidine structure
 Common Name N(4), O(2')-dimethylcytidine
CAS Number 13048-95-8 Molecular Weight 271.27
Density 1.54g/cm3 Boiling Point 475.4ºC at 760mmHg
Molecular Formula C11H17N3O5 Melting Point 203-205 °C
MSDS N/A Flash Point 241.3ºC

 Use of N(4), O(2')-dimethylcytidine


N4-Methyl-2’-O-methyl-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one
Synonym More Synonyms

 N(4), O(2')-dimethylcytidine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description N4-Methyl-2’-O-methyl-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.54g/cm3
Boiling Point 475.4ºC at 760mmHg
Melting Point 203-205 °C
Molecular Formula C11H17N3O5
Molecular Weight 271.27
Flash Point 241.3ºC
Exact Mass 271.11700
PSA 109.33000
Vapour Pressure 4.91E-11mmHg at 25°C
Index of Refraction 1.636
InChIKey BNXGRQLXOMSOMV-PEBGCTIMSA-N
SMILES CNc1ccn(C2OC(CO)C(O)C2OC)c(=O)n1

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xn

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

3',5'-di-O-acetyl-N4,2'-O-dimethylcytidine structure

3',5'-di-O-acet...

CAS#:1085342-83-1

~98%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Mahto, Santosh K.; Chow, Christine S. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8795 - 8800
4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine structure

4-N-methyl-3',5...

CAS#:110588-51-7

~92%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone structure

1-(3',5'-O-1,1,...

CAS#:108782-90-7

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone structure

1-(3',5'-O-1,1,...

CAS#:110567-19-6

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
1-((6aR,8R,9R,9aR)-2,2,4,4-tetraisopropyl-9-((trimethylsilyl)oxy)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione structure

1-((6aR,8R,9R,9...

CAS#:415903-48-9

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
Uridine structure

Uridine

CAS#:58-96-8

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830
3',5'-O-(1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANEDIYL)URIDINE structure

3',5'-O-(1,1,3,...

CAS#:69304-38-7

~%

N(4), O(2')-dimethylcytidine Structure

N(4), O(2')-dim...

CAS#:13048-95-8

Learn More
Literature: Nyilas, A.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 826 - 830

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

N,2'-O-Dimethylcytidine
Cytidine,N-methyl-2'-O-methyl
N4,O2'-Dimethylcytidin
N4,2'-O-dimethylcytidine
N4-Methyl-2'-O-methyl-cytidin
N4,O2'-dimethyl-cytidine

 N(4), O(2')-dimethylcytidine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: CAS number of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is 13048-95-8.
Q: What is the molecular weight of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Molecular weight of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is 271.27.
Q: What is the molecular formula of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Molecular formula of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is C11H17N3O5.
Q: What are the uses of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Main uses of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one: N4-Methyl-2’-O-methyl-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Q: What is the boiling point of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Boiling point of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is 475.4ºC at 760mmHg.
Q: What are the upstream materials of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Related upstream materials(CAS) of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one: 1085342-83-1;110588-51-7;108782-90-7;110567-19-6;415903-48-9;58-96-8;69304-38-7.
Q: What is the polar surface area (PSA) of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Polar surface area (PSA) of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is 109.33000.
Q: What is the melting point of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: Melting point of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is 203-205 °C.
Q: What English synonyms does 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one have?
A: English synonyms of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one: N,2'-O-Dimethylcytidine, Cytidine,N-methyl-2'-O-methyl, N4,O2'-Dimethylcytidin, N4,2'-O-dimethylcytidine, N4-Methyl-2'-O-methyl-cytidin, N4,O2'-dimethyl-cytidine.
Q: What is the SMILES notation of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one?
A: SMILES notation of 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-4-(methylamino)pyrimidin-2-one is CNc1ccn(C2OC(CO)C(O)C2OC)c(=O)n1.

 N(4), O(2')-dimethylcytidinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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