Ursodiol
Modify Date: 2024-01-02 17:27:24
Ursodiol structure
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Common Name | Ursodiol | ||
|---|---|---|---|---|
| CAS Number | 128-13-2 | Molecular Weight | 392.572 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 547.1±25.0 °C at 760 mmHg | |
| Molecular Formula | C24H40O4 | Melting Point | 203-206 ºC | |
| MSDS | Chinese USA | Flash Point | 298.8±19.7 °C | |
Use of UrsodiolUrsodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation. |
| Name | Ursodeoxycholic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.1±25.0 °C at 760 mmHg |
| Melting Point | 203-206 ºC |
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.572 |
| Flash Point | 298.8±19.7 °C |
| Exact Mass | 392.292664 |
| PSA | 77.76000 |
| LogP | 4.66 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Storage condition | 2~8°C |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... |
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[Preventive administration of new UDCA derivatives in experimental alcoholic steatohepatitis].
Eksp. Klin. Farmakol. 76(1) , 25-9, (2013) We have studied the prophylactic effect of new derivatives of ursodeoxycholic acid (UDCA), including UDCA-N-acetylcysteine, UDCA-L-acetylcysteine, and nor-UDCA (in doses equivalent to 40 mg/kg of UDCA... |
| (3a,5b,7b,8x)-3,7-dihydroxycholan-24-oic acid |
| Ursofalk |
| 17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7b-diol |
| 3α,7β-Dihydroxy-6β-cholan-24-oic acid |
| Ursolvan |
| Ursochol |
| Peptarom |
| (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
| Actigall |
| Delursan |
| Ursodeoxycholic acid |
| (3α,5β,7β)-3,7-Dihydroxycholan-24-oic acid |
| 3a,7b-dihydroxy-5b-cholan-24-oic acid |
| (3α,5β,7β,8ξ,20R)-3,7-Dihydroxycholan-24-oic acid |
| Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7β)- |
| Litursol |
| Cholit-ursan |
| (3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid |
| 3,7-Dihydroxycholan-24-oic acid |
| 3α,7β-dihydroxy-5β-cholan-24-oic acid |
| (3a,5b,7b)-3,7-Dihydroxycholan-24-oic Acid |
| cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7b,8x)- |
| Ursacol |
| Ursodiol |
| Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7β,8ξ,20R)- |
| 3a,7b-Dioxycholanic Acid |
| Destolit |
| MFCD00003680 |
| 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid |
| Arsacol |
| EINECS 204-879-3 |
- BioBioPha
- China
- Product Name: Ursodiol
- Price: ￥Inquiry/50mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ursodiol
- Price: ￥458.0/25g ￥128.0/5g ￥78.0/20mg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Ursodeoxycholic acid
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Ursodeoxycholic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Ursodiol
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Ursodeoxycholic acid
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: ￥95.5/5g
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