Eksperimental'naia i klinicheskaia farmakologiia 2013-01-01

[Preventive administration of new UDCA derivatives in experimental alcoholic steatohepatitis].

E B Belonovskaia, E E Naruta, O Ia Lukivskaia, V Z Abakumov, V U Buko

Index: Eksp. Klin. Farmakol. 76(1) , 25-9, (2013)

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Abstract

We have studied the prophylactic effect of new derivatives of ursodeoxycholic acid (UDCA), including UDCA-N-acetylcysteine, UDCA-L-acetylcysteine, and nor-UDCA (in doses equivalent to 40 mg/kg of UDCA) on the development of experimental alcoholic steatohepatitis induced by the Lieber-DeCarli liquid ethanol-containing diet. Results demonstrated that most of the investigated compounds produced a hepatoprotective effect, improving biochemical tests and liver morphology, as manifested by decreasing steatosis intensity, activity of alkaline phosphatase and gamma-glutamyltranspeptidase, triglyceride level in blood serum and liver, and TNF alpha content. However, nor-UDCA was most effective as compared to UDCA in preventing the accumulation of triglycerides in the liver.