128-13-2

128-13-2 structure

Name: Ursodiol
Chemical Name: Ursodeoxycholic acid
CAS Number: 128-13-2
Molecular Formula: C₂₄H₄₀O₄
Molecular Weight: 392.572
Catalog: API Digestive system medication Biliary medicine
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-02 17:27:24
Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation.

Name	Ursodeoxycholic acid
Synonyms	(3a,5b,7b,8x)-3,7-dihydroxycholan-24-oic acid Ursofalk 17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7b-diol 3α,7β-Dihydroxy-6β-cholan-24-oic acid Ursolvan Ursochol Peptarom (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Actigall Delursan Ursodeoxycholic acid (3α,5β,7β)-3,7-Dihydroxycholan-24-oic acid 3a,7b-dihydroxy-5b-cholan-24-oic acid (3α,5β,7β,8ξ,20R)-3,7-Dihydroxycholan-24-oic acid Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7β)- Litursol Cholit-ursan (3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid 3,7-Dihydroxycholan-24-oic acid 3α,7β-dihydroxy-5β-cholan-24-oic acid (3a,5b,7b)-3,7-Dihydroxycholan-24-oic Acid cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7b,8x)- Ursacol Ursodiol Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7β,8ξ,20R)- 3a,7b-Dioxycholanic Acid Destolit MFCD00003680 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid Arsacol EINECS 204-879-3

Description	Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation.
Related Catalog	Natural Products >> Steroids Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7. [2]. Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan;16(1):3-14.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	FZ2000000