MS-1020

Modify Date: 2024-01-08 17:37:15

MS-1020 structure	Common Name	MS-1020
	CAS Number	1255516-86-9	Molecular Weight	346.379
	Density	1.4±0.1 g/cm3	Boiling Point	711.2±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₈N₂O₃	Melting Point	N/A
	MSDS	USA	Flash Point	383.9±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of MS-1020

MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].

Name	ms-1020
Synonym	More Synonyms

Description	MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	JAK3
In Vitro	MS-1020 (0-50 µM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells[1]. MS-1020 (0, 10, 30 , 50 µM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels[1]. MS-1020 (0, 10, 30 , 50 µM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells[1]. MS-1020 (0, 10, 30 , 50 µM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells[1]. MS-1020 (0, 10, 30 , 50 µM; 72 h) induces apoptosis in L540 cells[1]. Western Blot Analysis[1] Cell Line: L540, HDLM-2, MDA-MB-468 cells Concentration: 0, 10, 30, 50 µM Incubation Time: Result: Decreased the expression of tyrosine phosphorylated STAT3 levels in a dose-dependent manner and showed no changes on total STAT3 levels. Cell Viability Assay[1] Cell Line: L540, HDLM-2 cells Concentration: 0, 10, 30, 50 µM Incubation Time: 72 h Result: Promoted cell death in a time- and dose-dependent manner only in L540 cells. Apoptosis Analysis[1] Cell Line: L540 cells Concentration: 0, 10, 30, 50 µM Incubation Time: 72 h Result: Induced apoptosis in L540 cells and increased the expression of cleavage of Poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3 and cleaved caspase-3, decreased the expression of Bcl-2, Bcl-xL, Mcl-1, and survivin in a dose-dependent manner.
References	[1]. Kim BH, et al. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148(1):132-43.

Density	1.4±0.1 g/cm3
Boiling Point	711.2±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₈N₂O₃
Molecular Weight	346.379
Flash Point	383.9±32.9 °C
Exact Mass	346.131744
PSA	85.35000
LogP	3.20
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.758

MS-1020 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport

1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthamide

2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-

DC Chemicals Limited
China
Product Name: MS-1020
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

MS-1020 suppliers

MS-1020 price

MS-1020

Use of MS-1020

Names

MS-1020 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms