2059892-29-2
2059892-29-2 structure
- Name: MS-453
- Chemical Name: N-(3-{[6,7-Dimethoxy-2-(1-pyrrolidinyl)-4-quinazolinyl]amino}propyl)acrylamide
- CAS Number: 2059892-29-2
- Molecular Formula: C20H27N5O3
- Molecular Weight: 385.460
- Create Date: 2020-01-11 15:59:50
- Modify Date: 2024-04-02 17:34:52
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A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM; exhibits selectivity for SETD8 against 28 other methyltransferases; does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM; poor membrane permeability (4.4 nm/s) and high efflux ratio (137).
| Name | N-(3-{[6,7-Dimethoxy-2-(1-pyrrolidinyl)-4-quinazolinyl]amino}propyl)acrylamide |
|---|---|
| Synonyms |
2-Propenamide, N-[3-[[6,7-dimethoxy-2-(1-pyrrolidinyl)-4-quinazolinyl]amino]propyl]-
N-(3-{[6,7-Dimethoxy-2-(1-pyrrolidinyl)-4-quinazolinyl]amino}propyl)acrylamide |
| Description | A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM; exhibits selectivity for SETD8 against 28 other methyltransferases; does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM; poor membrane permeability (4.4 nm/s) and high efflux ratio (137). |
|---|---|
| References | References 1. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H27N5O3 |
| Molecular Weight | 385.460 |
| Exact Mass | 385.211395 |
| LogP | 0.59 |
| Index of Refraction | 1.614 |