1255516-86-9
1255516-86-9 structure
- Name: MS-1020
- Chemical Name: ms-1020
- CAS Number: 1255516-86-9
- Molecular Formula: C21H18N2O3
- Molecular Weight: 346.379
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2017-02-11 12:21:59
- Modify Date: 2024-01-08 17:37:15
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MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].
| Name | ms-1020 |
|---|---|
| Synonyms |
1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthamide
2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]- |
| Description | MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK3 |
| In Vitro | MS-1020 (0-50 µM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells[1]. MS-1020 (0, 10, 30 , 50 µM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels[1]. MS-1020 (0, 10, 30 , 50 µM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells[1]. MS-1020 (0, 10, 30 , 50 µM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells[1]. MS-1020 (0, 10, 30 , 50 µM; 72 h) induces apoptosis in L540 cells[1]. Western Blot Analysis[1] Cell Line: L540, HDLM-2, MDA-MB-468 cells Concentration: 0, 10, 30, 50 µM Incubation Time: Result: Decreased the expression of tyrosine phosphorylated STAT3 levels in a dose-dependent manner and showed no changes on total STAT3 levels. Cell Viability Assay[1] Cell Line: L540, HDLM-2 cells Concentration: 0, 10, 30, 50 µM Incubation Time: 72 h Result: Promoted cell death in a time- and dose-dependent manner only in L540 cells. Apoptosis Analysis[1] Cell Line: L540 cells Concentration: 0, 10, 30, 50 µM Incubation Time: 72 h Result: Induced apoptosis in L540 cells and increased the expression of cleavage of Poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3 and cleaved caspase-3, decreased the expression of Bcl-2, Bcl-xL, Mcl-1, and survivin in a dose-dependent manner. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 711.2±60.0 °C at 760 mmHg |
| Molecular Formula | C21H18N2O3 |
| Molecular Weight | 346.379 |
| Flash Point | 383.9±32.9 °C |
| Exact Mass | 346.131744 |
| PSA | 85.35000 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.758 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |