206862-30-8
206862-30-8 structure
- Name: MS-377
- Chemical Name: MS-377
- CAS Number: 206862-30-8
- Molecular Formula: C18H26ClN3O2
- Molecular Weight: 351.875
- Create Date: 2020-01-11 16:33:51
- Modify Date: 2025-08-25 18:35:54
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MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities; markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain. Schizophrenia Discontinued
| Name | MS-377 |
|---|
| Description | MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities; markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain. Schizophrenia Discontinued |
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| References | References 1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302. 2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7. 3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4. 4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9. View Related Products by Target Sigma Receptor Schizophrenia |
| Molecular Formula | C18H26ClN3O2 |
|---|---|
| Molecular Weight | 351.875 |