d-Corlin

Modify Date: 2024-01-02 18:12:35

d-Corlin Structure
d-Corlin structure
Common Name d-Corlin
CAS Number 125-10-0 Molecular Weight 400.46
Density 1.3±0.1 g/cm3 Boiling Point 582.0±50.0 °C at 760 mmHg
Molecular Formula C23H28O6 Melting Point 240-242°C (dec.)
MSDS N/A Flash Point 200.2±23.6 °C

 Use of d-Corlin


Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].

 Names

Name cortancyl
Synonym More Synonyms

 d-Corlin Biological Activity

Description Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].
Related Catalog
Target

glucocorticoid receptor[1]

References

[1]. Prednisolone acetate

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 582.0±50.0 °C at 760 mmHg
Melting Point 240-242°C (dec.)
Molecular Formula C23H28O6
Molecular Weight 400.46
Flash Point 200.2±23.6 °C
Exact Mass 400.188599
PSA 97.74000
LogP 2.66
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.580
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4154085
CHEMICAL NAME :
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate
CAS REGISTRY NUMBER :
125-10-0
BEILSTEIN REFERENCE NO. :
2342061
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H28-O6
MOLECULAR WEIGHT :
400.51
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
330 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
135 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3270 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1045 (estimated) No. of Female Employees: 1045 (estimated)

 Synthetic Route

~99%

d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Lapitskaya, Margarita A.; Vasiljeva, Ljudmila L.; Pivnitsky, Kasimir K. Mendeleev Communications, 2008 , vol. 18, # 6 p. 309 - 311

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d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Journal of the American Chemical Society, , vol. 77, p. 4781,4783

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d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Journal of the American Chemical Society, , vol. 77, p. 4436

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d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Helvetica Chimica Acta, , vol. 39, p. 734,741 Recueil des Travaux Chimiques des Pays-Bas, , vol. 75, p. 475,480

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d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Heterocyclic Communications, , vol. 9, # 6 p. 575 - 578

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d-Corlin Structure

d-Corlin

CAS#:125-10-0

Literature: Journal of Pharmaceutical Sciences, , vol. 72, # 1 p. 30 - 35

 Customs

HS Code 2937210000

 Synonyms

d-Corlin
δ-Cortelan
Pregna-1,4-diene-3,11,20-trione, 21- (acetyloxy)-17-hydroxy-
Prednisone 21-acetate
EINECS 204-726-0
17-Hydroxy-3,11,20-trioxopregna-1,4-dien-21-yl acetate
Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
δ-Corlin
d-Cortelan
MFCD00200229