947257-66-1

947257-66-1 structure

Name: D-3263
Chemical Name: 3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]ca rbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one
CAS Number: 947257-66-1
Molecular Formula: C₂₁H₃₁N₃O₃
Molecular Weight: 373.48900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2016-03-05 14:48:39
Modify Date: 2024-01-10 17:00:35
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

Name	3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]ca rbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one
Synonyms	D-3263

Description	D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer
In Vitro	D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].
In Vivo	D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].
References	[1]. David Duncan, et al. PRECLINICAL EVALUATION OF THE TRPM8 ION CHANNEL AGONIST D-3263 FOR BENIGN PROSTATIC HYPERPLASIA. THE JOURNAL OF UROLOGY, Vol. 181, No. 4, Supplement, Tuesday, April 28, 2009