L-663581

Modify Date: 2024-02-04 16:13:11

L-663581 structure	Common Name	L-663581
	CAS Number	122384-14-9	Molecular Weight	357.79400
	Density	1.5g/cm3	Boiling Point	624.1ºC at 760mmHg
	Molecular Formula	C₁₇H₁₆ClN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	331.3ºC

Use of L-663581

L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor[1].

Name	7-chloro-5-methyl-3-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Synonym	More Synonyms

Description	L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. M D Tricklebank, et al. The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor. Br J Pharmacol. 1990 Nov;101(3):753-61.

Density	1.5g/cm3
Boiling Point	624.1ºC at 760mmHg
Molecular Formula	C₁₇H₁₆ClN₅O₂
Molecular Weight	357.79400
Flash Point	331.3ºC
Exact Mass	357.09900
PSA	77.05000
LogP	3.22260
Vapour Pressure	1.7E-15mmHg at 25°C
Index of Refraction	1.719

7-chloro-5,6-di...

CAS#:106937-66-0

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

N/A

CAS#:99622-53-4

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

7-chloro-5,6-di...

CAS#:84378-33-6

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

Formamide, N-[[...

CAS#:122384-65-0

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

3-(isocyanometh...

CAS#:122384-66-1

3,4-dihydro-4-m...

CAS#:78755-99-4

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

Sarmazenil

CAS#:78771-13-8

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

3,4-dihydro-4-m...

CAS#:78755-99-4

L-663581

CAS#:122384-14-9

Literature: Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

Precursor 6
CAS#:78771-13-8 Sarmazenil CAS#:78755-99-4 3,4-dihydro-4-m... CAS#:106937-66-0 7-chloro-5,6-di... CAS#:84378-33-6 7-chloro-5,6-di...
CAS#:122384-65-0 Formamide, N-[[... CAS#:122384-66-1 3-(isocyanometh...
DownStream 0

[14C]-FG 8205

7-chloro-5,6-dihydro-3-(5-isopropyl-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo<1,5-a><1,4>benzodiazepine

FG 8205

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3

L-663581

Use of L-663581

Names

L-663581 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms