Naspm
Modify Date: 2025-08-25 00:06:52
Naspm structure
|
Common Name | Naspm | ||
|---|---|---|---|---|
| CAS Number | 122306-11-0 | Molecular Weight | 370.53 | |
| Density | 1.062g/cm3 | Boiling Point | 608.9ºC at 760mmHg | |
| Molecular Formula | C22H34N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 322.1ºC | |
Use of NaspmNaspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. |
| Name | Naspm trihydrochloride,N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamidetrihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. |
|---|---|
| Related Catalog | |
| In Vitro | NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1]. |
| References |
| Density | 1.062g/cm3 |
|---|---|
| Boiling Point | 608.9ºC at 760mmHg |
| Molecular Formula | C22H34N4O |
| Molecular Weight | 370.53 |
| Flash Point | 322.1ºC |
| PSA | 79.18000 |
| LogP | 4.83560 |
| Vapour Pressure | 9.01E-15mmHg at 25°C |
| Index of Refraction | 1.569 |
| Storage condition | 2-8℃ |
| Safety Phrases | S22 |
|---|
| 1-naphthylacetylspermine |
| NASPM trihydrochloride |
| Naspm |