Citiolone

Modify Date: 2025-08-25 12:05:06

Citiolone Structure
Citiolone structure
 Common Name Citiolone
CAS Number 1195-16-0 Molecular Weight 159.20600
Density 1.263 g/cm3 Boiling Point 427.265ºC at 760 mmHg
Molecular Formula C6H9NO2S Melting Point 109-111ºC
MSDS Chinese USA Flash Point 212.202ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Citiolone


Citiolone is a derivative of the amino acid cysteine, used in liver therapy.

 Names

Name N-(Tetrahydro-2-oxo-3-thienyl)acetamide
Synonym More Synonyms

 Citiolone Biological Activity

Description Citiolone is a derivative of the amino acid cysteine, used in liver therapy.
Related Catalog

 Chemical & Physical Properties

Density 1.263 g/cm3
Boiling Point 427.265ºC at 760 mmHg
Melting Point 109-111ºC
Molecular Formula C6H9NO2S
Molecular Weight 159.20600
Flash Point 212.202ºC
Exact Mass 159.03500
PSA 71.47000
LogP 0.54550

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8680000
CHEMICAL NAME :
Acetamide, N-(tetrahydro-2-oxo-3-thienyl)-
CAS REGISTRY NUMBER :
1195-16-0
BEILSTEIN REFERENCE NO. :
0004338
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H9-N-O2-S
MOLECULAR WEIGHT :
159.22
WISWESSER LINE NOTATION :
T5SVTJ CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,362,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6028 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T,Xi
Risk Phrases R25
Safety Phrases 22-24/25-45-36-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AC8680000
HS Code 2934999090

 Synthetic Route

Silver acetate structure

Silver acetate

CAS#:563-63-3

~%

Citiolone Structure

Citiolone

CAS#:1195-16-0

Literature: Journal of the American Chemical Society, , vol. 78, p. 1597
3-Aminodihydro-2(3H)-thiophenone hydrochloride structure

3-Aminodihydro-...

CAS#:6038-19-3

Acetyl chloride structure

Acetyl chloride

CAS#:75-36-5

~%

Citiolone Structure

Citiolone

CAS#:1195-16-0

Literature: Chemical Communications, , vol. 49, # 54 p. 6057 - 6059

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles25

More Articles
Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.

Endocrinology 130(5) , 2851-7, (1992)

The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human ...

Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury.

Pharmacol. Toxicol. 69(1) , 71-4, (1991)

Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride...

Recurrent fixed drug eruption caused by citiolone.

J. Investig. Allergol. Clin. Immunol. 7(3) , 193-4, (1997)

Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolyt...

 Synonyms

EINECS 214-793-8
3-Acetamidotetrahydro-2-thiophenone
N-Acetyl-DL-homocystein thiolactone
MFCD00005480
N-(2-oxothiolan-3-yl)acetamide
2-Acetamido-4-mercaptobutyric Acid γ-Thiolactone
DL-N-Acetylhomocysteine thiolactone
Citiolone
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