Citiolone
Names
[ CAS No. ]:
1195-16-0
[ Name ]:
Citiolone
[Synonym ]:
EINECS 214-793-8
3-Acetamidotetrahydro-2-thiophenone
N-Acetyl-DL-homocystein thiolactone
MFCD00005480
N-(2-oxothiolan-3-yl)acetamide
2-Acetamido-4-mercaptobutyric Acid γ-Thiolactone
DL-N-Acetylhomocysteine thiolactone
Citiolone
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.263 g/cm3
[ Boiling Point ]:
427.265ºC at 760 mmHg
[ Melting Point ]:
109-111ºC
[ Molecular Formula ]:
C6H9NO2S
[ Molecular Weight ]:
159.20600
[ Flash Point ]:
212.202ºC
[ Exact Mass ]:
159.03500
[ PSA ]:
71.47000
[ LogP ]:
0.54550
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC8680000
- CHEMICAL NAME :
- Acetamide, N-(tetrahydro-2-oxo-3-thienyl)-
- CAS REGISTRY NUMBER :
- 1195-16-0
- BEILSTEIN REFERENCE NO. :
- 0004338
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C6-H9-N-O2-S
- MOLECULAR WEIGHT :
- 159.22
- WISWESSER LINE NOTATION :
- T5SVTJ CMV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,362,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6028 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T,Xi
[ Risk Phrases ]:
R25
[ Safety Phrases ]:
22-24/25-45-36-26
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
AC8680000
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Endocrinology 130(5) , 2851-7, (1992)
The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human ...
Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury.Pharmacol. Toxicol. 69(1) , 71-4, (1991)
Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride...
Recurrent fixed drug eruption caused by citiolone.J. Investig. Allergol. Clin. Immunol. 7(3) , 193-4, (1997)
Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolyt...