Recurrent fixed drug eruption caused by citiolone.

M de Barrio, P Tornero, A Prieto, T Sainza, J M Zubeldia, T Herrero

Index: J. Investig. Allergol. Clin. Immunol. 7(3) , 193-4, (1997)

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Abstract

Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic-derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely.