Danofloxacin Mesylate

Modify Date: 2024-01-02 14:46:20

Danofloxacin Mesylate structure	Common Name	Danofloxacin Mesylate
	CAS Number	119478-55-6	Molecular Weight	453.484
	Density	N/A	Boiling Point	569.3ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₄FN₃O₆S	Melting Point	337-339ºC
	MSDS	N/A	Flash Point	298.1ºC

Use of Danofloxacin Mesylate

Danofloxacin Mesylate(CP76136-27 mesylate) is a fluoroquinolone antibacterial for veterinary use.Target: AntibacterialDanofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml [1]. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay [2].

Name	Danofloxacin Mesylate
Synonym	More Synonyms

Description	Danofloxacin Mesylate(CP76136-27 mesylate) is a fluoroquinolone antibacterial for veterinary use.Target: AntibacterialDanofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml [1]. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Natural Products >> Alkaloid Research Areas >> Infection
References	[1]. Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14(4): p. 400-10. [2]. McGuirk, P.R., et al., Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. J Med Chem, 1992. 35(4): p. 611-20.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Natural Products >> Alkaloid

Research Areas >> Infection

References

[1]. Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14(4): p. 400-10.

[2]. McGuirk, P.R., et al., Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. J Med Chem, 1992. 35(4): p. 611-20.

Boiling Point	569.3ºC at 760 mmHg
Melting Point	337-339ºC
Molecular Formula	C₂₀H₂₄FN₃O₆S
Molecular Weight	453.484
Flash Point	298.1ºC
Exact Mass	453.136993
PSA	128.53000
LogP	2.65410
Vapour Pressure	8.41E-14mmHg at 25°C
Storage condition	0-6°C

Hazard Codes	T+
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

CP 76136-27

Danofioxacin Mesylate

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-, methanesulfonate (1:1)

MFCD00673687

1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic Acid Monomethanesulfonate

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1)

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate (1:1)

Danofloxacin mesylate

Danofloxacin (mesylate)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Danofloxacin Mesylate
Price: ￥678.0/100mg ￥736.0/5mg ￥3406.0/50mg ￥2086.0/25mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Danofloxacin Mesylate
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Danofloxacin mesylate
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Purity: 98.0%
Stocking Period: Inquiry
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Danofloxacin mesylate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Danofloxacin mesylate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Danofloxacin Mesylate

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