N-Cbz-L-Phenylalanine

Modify Date: 2025-08-22 11:56:08

N-Cbz-L-Phenylalanine Structure
N-Cbz-L-Phenylalanine structure
 Common Name N-Cbz-L-Phenylalanine
CAS Number 1161-13-3 Molecular Weight 299.321
Density 1.2±0.1 g/cm3 Boiling Point 511.5±50.0 °C at 760 mmHg
Molecular Formula C17H17NO4 Melting Point 85-87 °C(lit.)
MSDS USA Flash Point 263.1±30.1 °C

 Use of N-Cbz-L-Phenylalanine


Z-Phe-OH is a phenylalanine derivative[1].

 Names

Name N-Cbz-L-Phenylalanine
Synonym More Synonyms

 N-Cbz-L-Phenylalanine Biological Activity

Description Z-Phe-OH is a phenylalanine derivative[1].
Related Catalog
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-883.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 511.5±50.0 °C at 760 mmHg
Melting Point 85-87 °C(lit.)
Molecular Formula C17H17NO4
Molecular Weight 299.321
Flash Point 263.1±30.1 °C
Exact Mass 299.115753
PSA 75.63000
LogP 3.58
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.591

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY4343000
CHEMICAL NAME :
Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-
CAS REGISTRY NUMBER :
1161-13-3
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H17-N-O4
MOLECULAR WEIGHT :
299.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
251 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1726,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R62
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AY4343000
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles5

More Articles
Effects of metalloendoproteinase inhibitors on secretion and intracellular free calcium in bovine adrenal chromaffin cells.

Biochim. Biophys. Acta 889(1) , 1-5, (1986)

The possible role of metalloendoproteinase in stimulus-secretion coupling in adrenal chromaffin cells was examined using the metalloendoproteinase inhibitors 1,10-phenanthroline and carbobenzoxy-Gly-P...

Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions.

Biochim. Biophys. Acta 1824(2) , 303-10, (2012)

The chemical shift of the carboxylate carbon of Z-tryptophan is increased from 179.85 to 182.82 ppm and 182.87 ppm on binding to thermolysin and stromelysin-1 respectively. The chemical shift of Z-phe...

Modification of a zinc proteinase from Bacillus mesentericus strain 76 by diethylpyrocarbonate.

Int. J. Pept. Protein Res. 37(4) , 325-30, (1991)

Diethylpyrocarbonate (DEPC) inactivated the neutral zinc proteinase from Bacillus mesentericus strain 76/Bacillus subtilis (MCP 76) by ethoxycarbonylation completely. Exposure of the enzyme to DEPC to...

 Synonyms

L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-
N-Cbz-L-phenylalanine
N-Benzyloxycarbonyl-L-phnylalanine
MFCD00020418
(S)-2-(Benzyloxycarbonylamino)-3-phenylpropanoicacid
Phenylalanine, N-[(phenylmethoxy)carbonyl]-
Z-L-Phenylalanine
EINECS 214-599-3
(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoic acid
N-[(Benzyloxy)carbonyl]phenylalanine
N-carbobenzyloxy-dl-phenylalanine
N-Carbobenzyloxy-L-phenylalanine
N-(Carbobenzyloxy)-L-phenylalanine
N-Carbobenzoxy-L-phenylalanine
(2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoic acid
(S)-2-(Benzyloxycarbonylamino)-3-phenylpropanoic acid
Z-Phe-OH
CBZ-L-Phenylalanine
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