KN 92 structure
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Common Name | KN 92 | ||
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CAS Number | 1135280-28-2 | Molecular Weight | 554.98000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H28ClN2O7PS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of KN 92KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). IC50 value:Target: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
Name | N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-4-methoxybenzenesulfonamide,phosphoric acid |
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Synonym | More Synonyms |
Description | KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). IC50 value:Target: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
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Related Catalog | |
References |
Molecular Formula | C24H28ClN2O7PS |
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Molecular Weight | 554.98000 |
Exact Mass | 554.10400 |
PSA | 154.59000 |
LogP | 5.51980 |
Storage condition | 2-8℃ |
KN92 phosphate |
FD5001 |
2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine,Phosphate |
kn-92 |
HMS3229H11 |
KN92-H3PO4 |
KN-92 (phosphate) |