KN-92 磷酸盐

• 常用名: KN-92 磷酸盐
• 英文名: KN 92
• CAS号: 1135280-28-2
• 分子量: 554.98000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₈ClN₂O₇PS
• 熔点: N/A
• 闪点: N/A

KN-92 磷酸盐用途

KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II（CaMKII）抑制剂，能竞争性阻断钙调蛋白与对应激酶的结合，Ki为370 nM。

KN-92 磷酸盐名称

• 中文名: KN-92 磷酸盐
• 英文名: N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-4-methoxybenzenesulfonamide,phosphoric acid

KN-92 磷酸盐生物活性

• 描述: KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 蛋白激酶
  研究领域 >> 其他
• 参考文献:

  [1]. Rokhlin OW, Guseva NV, Taghiyev AF et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35.

  [2]. An P, Zhu JY, Yang Y et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007 Mar 7;13(9):1445-8.

  [3]. Gao L, Blair LA, Marshall J. et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.

  [4]. Rezazadeh S, Claydon TW, Fedida D. et al. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther. 2006 Apr;317(1):292-9.

  [5]. Anderson ME, Braun AP, Wu Y et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

  [6]. Sumi M, Kiuchi K, Ishikawa T et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.

  [7]. Park SW, et al. CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling. J Endocrinol. 2018 Mar;236(3):151-165.

KN-92 磷酸盐物理化学性质

• 分子式: C₂₄H₂₈ClN₂O₇PS
• 分子量: 554.98000
• 精确质量: 554.10400
• PSA: 154.59000
• LogP: 5.51980
• InChIKey: XRQHWVVDNMJDEQ-IPZCTEOASA-N
• SMILES: COc1ccc(S(=O)(=O)Nc2ccccc2CN(C)CC=Cc2ccc(Cl)cc2)cc1.O=P(O)(O)O
• 储存条件: 2-8℃

KN-92 磷酸盐英文别名

• KN92 phosphate
• FD5001
• 2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine,Phosphate
• kn-92
• HMS3229H11
• KN92-H3PO4
• KN-92 (phosphate)