1431698-47-3

• 常用中文名：KN-92 盐酸盐
• 常用英文名：KN-92-hydrochloride
• CAS号：1431698-47-3
• 分子式：C₂₄H₂₆Cl₂N₂O₃S
• 分子量：493.45
• 相关类别： 信号通路 神经信号通路 蛋白激酶
• 发布时间：2018-05-21 08:00:00
• 更新时间：2024-01-05 17:30:54
• KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。

名称

• 中文名: KN-92 盐酸盐
• 英文名: KN-92 hydrochloride
• 英文别名: KN-92-hydrochloride; KN-92 (hydrochloride)

物化性质

• 分子式: C₂₄H₂₆Cl₂N₂O₃S
• 分子量: 493.45
• 储存条件: 2-8℃

生物活性

• 描述: KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 蛋白激酶
  研究领域 >> 其他
• 参考文献:

  [1]. Rokhlin OW, Guseva NV, Taghiyev AF et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35.

  [2]. An P, Zhu JY, Yang Y et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007 Mar 7;13(9):1445-8.

  [3]. Gao L, Blair LA, Marshall J. et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.

  [4]. Rezazadeh S, Claydon TW, Fedida D. et al. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-

  [5]. Anderson ME, Braun AP, Wu Y et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

  [6]. Sumi M, Kiuchi K, Ishikawa T et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.