Gramicidin A
Gramicidin A structure
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Common Name | Gramicidin A | ||
|---|---|---|---|---|
| CAS Number | 11029-61-1 | Molecular Weight | 1882.29000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C99H140N20O17 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Gramicidin AGramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α). |
| Name | gramicidin a |
|---|---|
| Synonym | More Synonyms |
| Description | Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α). |
|---|---|
| Related Catalog |
| Molecular Formula | C99H140N20O17 |
|---|---|
| Molecular Weight | 1882.29000 |
| Exact Mass | 1881.07000 |
| PSA | 548.99000 |
| LogP | 11.26260 |
| Appearance of Characters | colorless or white |
| InChIKey | ZWCXYZRRTRDGQE-LUPIJMBPSA-N |
| SMILES | CC(C)CC(NC(=O)C(C)NC(=O)CNC(=O)C(NC=O)C(C)C)C(=O)NC(C)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCO)C(C)C)C(C)C)C(C)C |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | MD8230000 |
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Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen
FEBS Lett. 588(9) , 1590-5, (2014) • Unsaturated lipids protect gramicidin channels from photosensitized inactivation. • Photosensitizer binding to membrane is independent of lipid unsaturation. • Double bonds in lipids reduce gramicid... |
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Importance of indole N-H hydrogen bonding in the organization and dynamics of gramicidin channels.
Biochim. Biophys. Acta 1838(1 Pt B) , 419-28, (2014) The linear ion channel peptide gramicidin represents an excellent model for exploring the principles underlying membrane protein structure and function, especially with respect to tryptophan residues.... |
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Tonic GABAA conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network.
Proc. Natl. Acad. Sci. U. S. A. 111(1) , 504-9, (2014) The spiking output of interneurons is key for rhythm generation in the brain. However, what controls interneuronal firing remains incompletely understood. Here we combine dynamic clamp experiments wit... |
| MFCD00466944 |
| HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH |
| GrimicidinA(HighPurity),Bacillusbrevis |
| gramicidinafrombacillusbrevis |
| HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH |
| EINECS 234-259-8 |
| GRIMICIDIN A |
| OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH |