GW 833972A
GW 833972A structure
|
Common Name | GW 833972A | ||
|---|---|---|---|---|
| CAS Number | 1092502-33-4 | Molecular Weight | 444.23800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14Cl2F3N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of GW 833972AGW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. |
| Name | 2-(3-chloroanilino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. |
|---|---|
| Related Catalog | |
| Target |
hCB2-R:7.3 (pEC50) rat CB2-R:7.5 (pEC50) |
| In Vitro | GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化，还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。 |
| In Vivo | GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。 |
| References |
| Molecular Formula | C18H14Cl2F3N5O |
|---|---|
| Molecular Weight | 444.23800 |
| Exact Mass | 443.05300 |
| PSA | 83.29000 |
| LogP | 5.66720 |
| InChIKey | UBHSVFAUAKIVKL-UHFFFAOYSA-N |
| SMILES | Cl.O=C(NCc1ccncc1)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335-H413 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| Hazard Codes | T+ |
| Risk Phrases | 25-36/37/38 |
| Safety Phrases | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |
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| 2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride |